Shaheed Syed Nazrul Islam Medical College Journal
Volume 9, Issue 1, January 2024
Original Contribution
doi: https://doi.org/10.69699/ssnimcj.2024.v9.i1.05
Frequency Domain Parameters of Heart Rate Variability in Patients with Gastro-Oesophageal Reflux Disease
1. *Dr. Sukrana Mamataj, Assistant Professor, Physiology, Ahsania Mission Medical College.
dr.sukranamamataj@gmail.com
2. Dr. Mahin Motaleb, Assistant Professor, Anatomy, Ahsania Mission Medical College.
3. Dr. Sabrina Fahmida Azim, Associate Professor, Physiology, Kumudini Women’s Medical College
*For correspondence
Abstract
Background: Gastro-oesophageal reflux disease (GERD) has been associated with autonomic nervous dysfunction along with reduced Heart Rate Variability.
Objective: To observe cardiac autonomic nerve function status by heart rate variability analysis in patients with Gastro-oesophageal reflux disease (GERD).
Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from 1st January, 2017 to 31st December, 2017. Forthis, total 30 male and female diagnosed GERD patients from the Out Patient Department (OPD) of Gastroenterology, BSMMU aged 20-35 years were included in the study group. Low Frequency norm (LF norm),High Frequency norm (HF norm) and LF/HF ratio of HRV parameters were recorded. Thirty age and BMI matched healthy subject also included as control. For statistical analysis, unpaired t-test was done as applicable.
Results: The mean LF norm was 72.10±13.97 n.u. and the mean LF/HF was 3.34±1.14. Which were significantly (p<0.001) higher in GERD patients in comparison to that of healthy subjects. Which indicate sympathetic overactivity in GERD patients. However, the mean HF norm was 24.54±10.56 n.u. Which was significantly (p<0.001) lower in GERD patients as compared to that of apparently healthy subjects. Which indicate decreased parasympathetic activity in GERD patients.
Conclusion: Parasympathetic hypofunction and sympathetic over activity were found in GERD patients.
[Shaheed Syed Nazrul Islam Med Col J 2024, Jan; 9 (1):29-34]
Keywords: Heart rate variability, Gastro-oesophageal reflux disease (GERD)
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