Original Contribution
Biochemical and Hematological Changes in Patients of Chronic Kidney Disease
1. Dr. Abu Ayub Md. Nazmul Huda, Associate professor, Department of Nephrology, Shaheed Sayed Nazrul Islam
Medical College, Kishoreganj, Bangladesh. a2mnhuda71@gmail.com
2. Dr. Tofael Ahammod, Assistant Professor, Department of Nephrology, Shaheed Sayed Nazrul Islam Medical
College, Kishoreganj
3. Dr. Hasan Mahmud, Assistant Professor, Department of Nephrology. Shaheed Sayed Nazrul Islam Medical
College, Kishoreganj
*For correspondence
Abstract
Background: Chronic kidney disease-CKD is a major public health problem and cause of
morbidity and mortality worldwide. In Bangladeshi population, the prevalence of CKD is
unexpectedly high, because Diabetes and Hypertension are common in Bangladesh. CKD is
defined as impaired glomerular filtration rate (GFR) or elevated albumin excretion in the urine, and
has been recognized as an important risk factor contributing to cardiovascular disease and death.
There are many causes of CKD. Glomerulonephritis, diabetes mellitus, hypertension, interstitial
nephritis, Polycystic kidney disease are important causes.
Methods: This was a prospective observational study done Shaheed Sayed Nazrul Islam Medical
College, Kishoreganj from January 2022 to December 2022 to evaluate the biochemical profile in
patients of chronic kidney disease as compared to healthy controls. Analysis of lipid profile ( Total
cholesterol, HDL-C, LDL-C and Triglycerides), Renal profile (Creatinine, Electrolytes, Calcium,
Inorganic phosphate, Uric acid) and Hematological parameters including PTH were carried out in
CKD patients (n=100) and compared to the healthy individuals (n=100). Results were analyzed
statistically using SPSS 20 program for windows.
Results: Low level of hemoglobin which was statistically significant compared to the control
group (p<0.05). High level of PTH, serum creatinine, Potassium, inorganic phosphate, Uric acid
accompanied by low levels of calcium, were found statistically significant compared to the control
group (p<0.05).
Conclusion: Glomerulonephritis, diabetes and hypertension are the main causes of CKD. We
suggest stringent hematological and biochemical testing in the patients of CKD for proper
evaluation and accurate management to reduce the morbidity and mortality.
[Shaheed Syed Nazrul Islam Med Col J 2023, Jul; 8 (2):123-128]
Keywords: Chronic Kidney Disease (CKD), Hematological profile, Renal profile
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