Posted on by ssnimc

ssnimcj2024v9i2a7

Original Contribution

Biochemical and Serological Characteristics of Incidentally Detected Chronic Hepatitis B Infection

 

*Alam MJ,1 Mahtab M,2 Rahman MM,3 Ahmed MU,4 Rahman MO,5 Chowdhury MK,6 Shaha M7

 

  1. *Dr. M. Jahangir Alam, Department of Gastroenterology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh. jahangirk43@yahoo.com
  2. Masuma Mahtab­, Department of Radiology & Imaging, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh.
  3. Md Muhibur Rahman Department of Gastroenterology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
  4. Mostak U. Ahmed, Department of Gastroenterology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
  5. M. Oliur Rahman, Department of Gastroenterology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
  6. Malay K. S. Chowdhury3, Department of Gastroenterology, Colonel Maleque Medical College, Manikganj, Bangladesh.
  7. Madhusudan Saha, Department of Gastroenterology, Sylhet Women’s Medical College, Sylhet, Bangladesh.

 

*For correspondence

Abstract

Background: Hepatitis B virus infection is still a significant public health problem worldwide. In a considerable number of cases the infection person remains asymptomatic, despite ongoing histological activity.

Objective: This retrospective study was done to see biochemical and serological activity of hepatitis B virus in incidentally detected hepatitis B virus infected patients.

Methods: This cross-sectional study was conducted at Popular Medical Centre, Sylhet, Bangladesh, from January 2016 to December 2017.  Available demographic and laboratory data of incidentally detected patients of chronic hepatitis B virus infection were retrieved from record and analysed using SPSS version 20. Mean and SD for continuous data and percentage of categorical data were calculated.

Results: Total 276 patients, age ranging from 13 to 60 years (mean 29.38), male 225 (81.5%) were enrolled. Of them 147 (53.3%) were in 26 – 40 years age group. In this series, 157 (56.9%) and 54 (19.6%) had history of saloon shave and family history of liver disease respectively. Alanine aminotransferase (ALT) of them varied from 15 to 367 iu/dl (mean 51.54). Of them 37 (13.4%) had HBeAg positive and 17 (6.2%) had fatty liver in ultrasound.  HBV DNA was seen in 115 patients with 32 (27.82%) had DNA load above 100,000 copies per ml.

Conclusion: We observed a wide range of alanine aminotransferase (ALT) levels, with a  notable proportion of patients tested positive for HBeAg. Ultrasonography revealed fatty liver in a subset of patients. Hepatitis B virus DNA estimation showed a considerable prevalence, with a subset having high viral loads. Fibro-scan demonstrated varying degrees of liver stiffness. These findings underscore the importance of comprehensive assessment and monitoring in patients with incidentally detected chronic hepatitis B infection.

[Shaheed Syed Nazrul Islam Med Col J 2024, Jul; 9 (2):86-93]

DOI: https://doi.org/10.69699/ssnimcj2024v9i2a7

 

Keywords: Hepatitis B infection, Biochemical parameter, Serological parameter, incidentally detected.

Full Article in PDF

Proudly powered by WordPress