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ssnimcj2025v10i1s10

Original
Evaluation of Neutrophil-lymphocyte Ratio as a Predictor of Complications in Dengue Infection

*Wazib A,1 Rahman S,2 Belal MM,3 Shamme SS,4 Ahmed MR,5 Kamal FN,6 Mani SI,7 Kamal M8

 

  1. *Dr. Amit Wazib, FCPS (Medicine), MD (Neurology), Professor & Head, Department of Medicine, Shaheed Monsur Ali Medical College. amit.bcps.2552@gmail.com
  2. Dr. Shaila Rahman, FCPS (Medicine), MRCP (UK), Associate Professor, Department of Medicine, Shaheed Monsur Ali Medical College,
  3. Dr. Munshi Mohammad Belal, FCPS (Medicine),Assistant Professor, Department of Medicine, Shaheed Syed Nazrul Islam Medical College,
  4. Dr. Sheikh Shamsunnahar Shamme, FCPS (Paediatrics), Junior Consultant, Department of Paediatrics, Shaheed Syed Nazrul Islam Medical College Hospital,
  5. Dr. Md. Rayhan Ahmed, Assistant Registrar, Department of Medicine, Shaheed Monsur Ali Medical College Hospital
  6. Dr. Farah Naz Kamal, General Practitioner,
  7. Dr. Md. Shahidul Islam Mani, Intern, Department of Medicine, Shaheed Monsur Ali Medical College Hospital,
  8. Mehnaz Kamal, MPH (Epidemiology), Senior Manager, Research & Advocacy, BRAC Health Programme, BRAC

 *For correspondence

Abstract

Introduction: Dengue is an endemic infection in Bangladesh with frequent outbreaks. Severe dengue including dengue shock syndrome (DSS), severe haemorrhage and expanded dengue syndrome (EDS), is the major contributor of morbidity and mortality in dengue infection. This study aimed to assess the association of neutrophil-lymphocyte ratio (NLR) with severe dengue, DHF, DSS, severe haemorrhage and EDS in dengue fever.

Methods: This prospective study was conducted on 250 randomly selected dengue patients admitted under the Department of Medicine in Shaheed Monsur Ali Medical College Hospital, Dhaka, Bangladesh from July to December 2023. The study participants were divided into two groups – with NLR≥2 and NLR<2, on the third day of fever. Frequencies severe dengue, dengue haemorrhagic fever (DHF), DSS, severe haemorrhage and EDS were compared between the two groups.

Results: NLR ≥2 on the third day of fever was associated with a statistically significant higher frequency of DHF, DSS, EDS and severe dengue.

Conclusion: NLR can be used as a predictor of complications in dengue infection. Dengue patients with NLR ≥2 on the third day of fever possess a higher risk of developing complications, and hence need close monitoring.

[Shaheed Syed Nazrul Islam Med Col J 2025, Jan; 10 (1):73-80]

DOI: https://www.doi.org/10.69699/ssnimcj2025v10i1s10

Keywords: Neutrophil-lymphocyte ratio, dengue haemorrhagic fever, dengue shock syndrome, expanded dengue syndrome, severe dengue